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All Wrong About Alzheimer's

Alzheimer’s disease, a condition characterized by an accumulation of beta-amyloid plaques and neurofibrillary tangles in the brain, affects an estimated 5 million Americans; this number is expected to reach 14 million by 2060. With no known cure, researchers are scrambling to find treatments, often with a misguided focus on drugs designed to remove excess beta-amyloid in the brain. Drug development for Alzheimer’s has so far been a dismal failure, with 300 failed trials to date. Despite the history of letdowns, the latest failed drug trial is still making waves in the research community because there were high hopes that it would provide a breakthrough treatment for people with gene mutations known to cause Alzheimer’s. Now, with the experimental drugs failing to lead to improvements, researchers are asking if the focus on drugs to target and neutralize beta-amyloid in the brain is all wrong, and if other potential targets should become the focus of future research.  Read more....



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