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Aluminium in Brain Tissue in Multiple Sclerosis

Multiple sclerosis (MS) is a chronic, immune-mediated, demyelinating disease of the central nervous system of unknown aetiology. Despite some progress, advances in understanding the pathogenesis of MS remain frustratingly slow. Effective treatments for MS are rare. The consensus remains that MS is likely to involve both genetic and environmental factors acting either in isolation or together in various disease phenotypes. Human exposure to aluminium is identified as a possible contributor to MS. Individuals with relapsing remitting (RRMS) and secondary progressive (SPMS) MS were shown to excrete large amounts of aluminium in their urine, an observation recently built upon and confirmed in individuals with SPMS. The origin in the body of excreted aluminium, identified in aforementioned research, is unknown; although it may be brain tissue as myelin and oligodendrocytes are specific targets in animal models of aluminium intoxication. However, while data demonstrate the presence of aluminium in human brain tissue in neurodegenerative/neurodevelopmental disease, there are no such data for MS. Herein we have carried out the first quantitative measurements of aluminium in brain tissue for MS and supported these data with the first imaging of the location of aluminium in donor tissues.  Read more...

 

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