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Alzheimer's disease is a 'double-prion disorder'

Two proteins central to the pathology of Alzheimer's disease act as prions -- misshapen proteins that spread through tissue like an infection by forcing normal proteins to adopt the same misfolded shape -- according to new UC San Francisco research.  Using novel laboratory tests, the researchers were able to detect and measure specific, self-propagating prion forms of the proteins amyloid beta (A-β) and tau in postmortem brain tissue of 75 Alzheimer's patients. In a striking finding, higher levels of these prions in human brain samples were strongly associated with early-onset forms of the disease and younger age at death.  Read more....

 

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