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CRISPR Gene Editing Can Trigger Cancer, Two Studies Warn

CRISPR-Cas9, a form of “molecular scissors,” allows for very precise DNA editing, i.e., the removal, addition or altering of sections of a DNA sequence.  While CRISPR-Cas9 gene editing is more precise in that you can target a specific area of the genome, two recent studies warn the gene editing process can trigger cancer.  When you cut the two double helix strands of the DNA, the injury triggers the cell to activate a gene called p53 — a “biochemical first-aid kit” that either mends the DNA break or signals the cell to self-destruct; so, either the genome edit is mended or the cell dies.  In instances where the cell survives and accepts the edit, it does so because it has dysfunctional p53, and p53 dysfunction has been shown to significantly increase your risk of cancer.  Read more...



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