Ketogenic diet may boost targeted cancer therapy

A very low carbohydrate, high-fat diet called the ketogenic diet may improve the effectiveness of an emerging class of cancer drugs, according to a study in mice by investigators at Weill Cornell Medicine, Columbia University Irving Medical Center and NewYork-Presbyterian.  In a study published in Nature on July 4, scientists provide a possible explanation for why the drugs, which target the insulin-activated enzyme phosphatidylinositol-3 kinase (PI3K) whose mutations have been implicated in many cancers, haven't performed as well as hoped. And they identify a strategy that might boost the therapies' tumor-killing potential.  Read more...

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