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Metallic drivers of Alzheimer's disease

Alzheimer's disease is a neurodegenerative disease that is associated with dementia and shortened life expectancy. The disease is characterised by the formation of protein plaques and tangles in the brain that impair function. As well as protein plaques, perturbed metal ion homeostasis is also linked with pathogenesis, and iron levels in particular are elevated in certain regions of the brain.  A team of scientists with a long history in exploring biomineralisation in Alzheimer's brains set out to characterise the iron species that are associated with the amyloid protein plaques.   Read more...

 

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