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Microbiome provides new clues to determining development of colon cancer

A mutant protein found in humans with colon cancer blocks a pathway that regulates proliferation and expansion of cells, increasing amounts of bacterial species associated with the development of colon cancer. These findings, showcasing the connection between bacteria in the microbiome and colon cancer, were published by a team of researchers from the George Washington University (GW) in the journal Gastroenterology.  "Colon cancer is increasing in young people. Current guidelines recommend screening those over age 50 for colon cancer, but today we are seeing that 15% of those with colon cancer are under the age of 50," said Lopa Mishra, MD, director of the Center for Translational Medicine at the GW Cancer Center and professor of surgery at the GW School of Medicine and Health Sciences. "We hypothesized that diet and its effects on the microbiome may be big players, which is where we focused our study."  Read more.....

 

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