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Newborn mice exposed to general anesthetic experience disrupted brain development

The U.S. Food and Drug administration (FDA) has recently issued a safety advisory warning that exposure to anesthetic and sedative drugs during the period of time between the third trimester of prenatal development and the first three years of life may have lasting adverse effects on cognitive function. New research publishing July 6 in the open access journal PLOS Biology by Eunchai Kang, David Mintz and colleagues now shows that early postnatal mice exposed to isoflurane -- a standard and widely used inhaled general anesthetic agent -- leads to chronic, abnormal activation of the mTOR pathway, a signaling system critical for normal brain development.  Read more...

 

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