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The association between BMI and mortality: implications for obesity prevention

Excess adiposity is an established risk factor for all-cause mortality, likely mediated mainly through its effects on a wide range of chronic diseases, including several types of cancer, type 2 diabetes, and cardiovascular disease. In their population-based cohort study published in The Lancet Diabetes & Endocrinology, Krishnan Bhaskaran and colleagues1 found a J-shaped association between BMI and overall mortality among 3·6 million adults in the UK. This study provides further support for the strong association between increasing BMI and excess mortality at BMI of 25 kg/m2 or higher (estimated hazard ratio per 5 kg/m2 increase 1·21 [95% CI 1·20–1·22]). These observations are consistent with several recent studies, collectively representing tens of millions of participants globally.  The authors also report the association between BMI and deaths from specific causes, with optimal BMI in the range of 21–25 kg/m2 for cancer, cardiovascular, and respiratory deaths.  Read more...
 

 

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