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The Dengvaxia Disaster Was Twenty Years in the Making—What Will Happen With a Rushed COVID-19 Vaccine?

Vaccine development is a topic that is on the minds of everyone as the world grapples with ways to protect our health and the health of our loved ones from coronavirus. The team at Children’s Health Defense decided to write an article about Dengue Fever because an important part of medicine’s body of knowledge comes from the opportunity to learn from past mistakes. Dengue fever is a common disease in more that 120 countries and, like Coronavirus, has been the target for a vaccine for many years. The development and licensure of Dengvaxia® vaccine by Sanofi  spanned more than 20 years and cost more than 1.5 billion U.S. dollars. But the development of the vaccine turned out to be tricky. Dengue vaccine antibodies can also make the infection worse, especially in infants and children who have never been exposed to the virus. The virus may actually use the antibodies created by the vaccine to spread the virus throughout the body. So an infection with dengue — when your blood already has antibodies in it — can actually enhance the disease resulting in deadly complications.  Read more....

 

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